The voltammetric properties of entacapone, an anti-Parkinson’s disease drug, are investigated by cyclic voltammetry on two different working electrodes. In cyclic voltammetry, entacapone shows one well defined irreversible reduction peak at both the electrodes i.e. Glassy Carbon Electrode (GCE) and Platinum electrode. The influence of pH, concentration and scan rate has been studied. The experimental results prove that the reduction of entacapone is diffusion controlled, irreversible, four and two electron transfer process on glassy carbon and platinum electrode, respectively. A mechanism is proposed for the reduction of the sample. Calibration plots, regression data validation, accuracy, precision, and other aspects of analytical merit are presented.
