Two simple and sensitive visible spectrophotometric methods (Method-A and Method-B) have been developed for the determination of Losartan potassium in bulk drug and pharmaceutical formulations. The developed methods involve the formation of colored chloroform extractable ion-ion association complex of Losartan potassium with Bromo cresol purple (Method-A) and Bromo phenol blue (Method-b) in acid medium, exhibiting absorption maxima at 425 and 430nm respectively and obeying Beer’s law in the concentration range of 2.5 -12.5 μg/ml for the two methods with good correlation. Statistical analysis of the results of the proposed methods reveals high accuracy and good precision. The proposed methods could be successfully extended to the commercial pharmaceutical formulations containing Losartan potassium.
