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Visible light induced Biginelli reaction in fruit juice medium: A green strategy for synthesis of pharmaceutically active dihydropyrimidinones | Abstract
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Abstract

Visible light induced Biginelli reaction in fruit juice medium: A green strategy for synthesis of pharmaceutically active dihydropyrimidinones

Author(s): Tanay Pramanik, Simarjit Kaur Padan and Richa Gupta

A series of Dihydropyrimidinones (DHPM) containing both electron rich as well as electron deficient aromatic rings were synthesized with an excellent percentage of yields via visible light induced green Biginelli reactions in fruit juice medium. The series of Biginelli reactions were performed by employing an equimolar mixture of urea, ethyl acetoacetate and aromatic aldehyde as reactants whereas apple, pomegranate and grape juices were used as eco-friendly, bio-degradable and green reaction medium for the same. All the reactions were carried out by applying visible light irradiation as an eco-friendly source of energy. After completion of reactions, the crude DHPMs were purified through re-crystallization to obtain pure DHPMs which were further characterized by FTIR, 1H-NMR and 13C-NMR spectroscopy.