Changes in lactate dehydrogenase and creatine kinase in the plasma of the African catfish Clarias gariepinus (Burchell, 1822) subjected to sublethal concentrations (2.0; 6.0 and 10.0 mg/L) of potassium permanganate over a period of 192 hours were studied in a semistatic (renewal) system. Potassium permanganate exposure caused significant (P < 0.05) increases in alanine aminotransferase and aspartate aminotransferase. Increased activities of both aminotransferases indicated amplified transamination processes and were used as stress indicators.