Terbinafine Hydrochloride (TH) is a new potent antifungal agent. Many spectroscopic methods are developed using organic solvents, but inorganic solvents like hydrochloric acid, sodium hydroxide can also be used for the estimation of APIs depending on their solubility. UV-spectrophotometric method has been developed for the determination of TH in bulk and in tablet dosage form. For the determination of Terbinafine Hydrochloride, solvent system employed was 0.1N hydrochloric acid (HCl) and wavelength of detection was 223 nm. The aim of this study was to develop simple, sensitive, cost effective, accurate, precise, reproducible and rapid ultraviolet (UV) Spectrophotometric method for the determination of Terbinafine Hydrochloride in bulk and in tablet dosage form. The linearity and range for Terbinafine Hydrochloride in 0.1N HCl was found to be 1-3.5 μg/ml with coefficient of correlation (R2) value 0.995. The method was validated for precision, accuracy and sensitivity (LOD and LOQ).
