Der Pharmacia Lettre
Abstract
Author(s): Shubhangi M. Pawar, Jitendra D. Fegade, Rajesh Y. Chaudhari
This paper describes a new, simple, precise, and accurate HPLC method for simultaneous
quantitation of Domperidone Maleate (DOM) and Naproxen Sodium (NAP) as the bulk drug and
in tablet dosage form. Chromatographic separation of the drugs was achieved on a Eurosphere
C18 column (5 ?Ž?¼m, 250 mm ????? 4.6 mm, i.d.) with the isocratic mobile phase methanol: sodium
acetate buffer (60:40 v/v, pH 3.6 adjusted with acetic acid) at a flow rate of 1 mL/min. The UV
detection wavelength was 266 nm. The two drugs were satisfactorily resolved with retention
times 3.21 min and 7.45 min for DOM and NAP, respectively. Linearity was found to be in the
range of 10-60 ?Ž?¼g/mL for DOM and 25-150 ?Ž?¼g/mL for NAP with significantly high value of
correlation coefficient (0.9974 for DOM and 0.9992 for NAP). The percentage recovery
obtained was 98.86 % for DOM and 99.55 % for NAP.
