A simple, sensitive and accurate UV, first derivative, second derivative and two visible spectrophotometric methods were developed for the analysis of Trifluoperazine in pharmaceutical formulations. Method M1, M2 and M3 were based on the UV absorption of drug and first and second derivative calculation in UV region that shows absorption maxima at 220nm. Method M4 and M5 were based on the oxidative coupling reaction of drug with 1, 10 phenanthroline and Potassium ferricyanide that shows maximum absorbance at 520nm and 720nm respectively. Linearity range was found to be 2-12μg/ml for UV method [M1, M2 and M3], 8- 20μg/ml for 1,10 - phenanthroline method [M4] and 2-20μg/ml for Potassium ferricyanide method [M5]. The methods were validated as per ICH guidelines. The proposed methods have been applied for the estimation of Trifluoperazine in tablets. The developed method was simple, accurate, reliable and economical. The proposed method is specific and interference of excipients. Hence it can be used for the routine analysis of Trifluoperazine in bulk and in pharmaceutical formulation.
