In Sidha system of medicine use of salts prepared by herbal plants for treatment of diseases is common. Siruccini uppu, harbal salt of Acalypha fruticosa (Forssk) is used for the treatment of Gunmam, peptic ulcers. In the present study the efficacy of Sirucinni uppu was evaluated in rat model. Five groups of albino rats (150–200 gm), each group consisting of six animals were used. The first group served as a normal control group, which were given 5 ml normal saline/kg for normal comparison, the second group served as negative control, which were also given 5ml saline/kg. The third group animals were given Ranitidine 20 mg/kg body weight and served as positive control group. Fourth and fifth groups served as test groups. The fourth and fifth groups were treated respectively with ‘Sirucinni uppu’ (HSAF) in the dose of 200mg and 400 mg orally for 15 days. After 15 days of treatment, animals were fasted for 24 hours. Ulcer was produced by administration of aqueous suspension of aspirin (a dose of 200 mg/kg orally) on the day of sacrifice except normal control group animals. After four hours the animals were sacrificed and the stomach was excised along the greater curvature, washed carefully with 5.0 ml of 0.9 % saline and ulcers were scored by a person unaware of the experimental protocol in the glandular portion of the stomach and ulcer index is tabulated. The use of Sirucinni uppu has given better results compared to ranitidine treatment as anti ulcer agent and it is suggested that the use of this drug should be more common as compared to the chemical, ranitidine.
