An ethnobotanical survey was carried out among the ethnic group namely, Malayali tribes in Pachaimalai Hills, Tamil Nadu, India. The tribal communities of Malayali cherish rich knowledge about medicinal plants and their uses. Therefore, we have done a comprehensive ethnobotanical survey in this area. In this present investigation, it is observed that the tribal used 80 wild valuable plant species belonging to 42 families were identified with relevant informations and documented in this paper with their botanical names, families, local names, parts used and their utility against different human ailments. The common diseases treated by the herbal practitioners were asthma, digestive problems, paralyzes, skin diseases and diabetes.