Njasang (Ricinodendron heudelotii) and Ehuru (Monodora myristica) are used in some parts of Nigeria both as spices and in the treatment of various ailments. This study was conducted to investigate the toxic effect of n-hexane oil extract of these spices on rat liver and kidney functions. Twenty five albino rats were divided into five groups of five rats each. The mixed oil from the spices were administered alongside with olive oil in the ratio of 1:3ml, 1:2ml and 1:1ml (olive oil: oil extract) to rats in groups 1, 2 and 3 respectively. Group 4 rats received only 2ml olive oil and group 5 (control) received 0.9% normal saline daily for 28 days. The blood samples were collected via cardiac puncture and were assayed for serum enzyme activities (ALT, AST and ALP), Electrolytes (Na+, K+ and Cl-) and other biochemical (Urea, Creatinine, Total protein and Total Bilirubin). The result showed significant (P < 0.05) increase for ALT and AST at the various dose levels of the test samples compared with the control, while ALP increased only at a higher dose level (1:3ml). Results for serum electrolytes showed a dose-dependent increase in Na+ and Cl- concentrations, while K+ decreased in the entire tested group. The effect of the various doses on serum Urea, Creatinine and Total Bilirubin increased significantly (P < 0.05) while Total Protein showed a non significant (P > 0.05) decrease at various dose levels. Olive oil treated group had a decreased effect in the concentrations of all the parameters studied except for Total Protein.
