α-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of panisidine( 1), dimethylphosphite(3), and different aromatic aldehydes (2a-j) by Kabachnik–Fields reaction in the presence of tetramethylguanidine(TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.
