Thiazolo-Triazole is a fused ring heterocyclic system consisting of three nitrogen atoms and one Sulphur atom shows wide range of biological activities. Thiazolo-Triazole can be synthesized using Regioselective and electro synthesis methods.Thiazolo-Triazole possess wide spectrum of biological activities like including antibacterial, antifungal, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and Diuretic properties. The present reviews attempted to gather the various developments in synthesis and biological activities of Thiazolo- Triazole derivatives.