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Thiazolidinone: Synthesis and biological studies | Abstract
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Abstract

Thiazolidinone: Synthesis and biological studies

Author(s): Bhut Dipakkumar Narsibhai, Diva Mishra, Lochan V. Vyavahare, Arun Singh

2-(5-benzoyl-1H-benzo[d][1,2,3]triazol-1-yl)acetohydrazide (3) undergoes facile condensation with aromatic aldehydes to afford the corresponding 2-(5-benzoyl-1H-benzo[d][1,2,3]triazol-1-yl)-N'-arylidene aceto hydrazide (4a-d) in good yields. Cyclocondensation of compounds (4a-d) with thioglycolic acid yields 3-(2-(5-benzoyl-1Hbenzo[ d][1,2,3]triazol-1-yl)acetyl)-2-arylthiazolidin-4-one (5a-d). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.