Objective of the present study was to develop and evaluate thermoreversible in situ gelling drug delivery system for periodontal anasthesia. This system improves patient compliance by giving anesthesia at a site without distress of needle insertion. Thermoreversible gels were prepared by combining different concentration of pluronics F127 and F68. Formulations were evaluated in terms of their viscosity, gel strength, gelation temperature, stability and in vitro drug release. The formulations were stored at different temperature and humidity. The formulation has amide group anesthetic agent for delivery into periodontal pocket containing mepivacaine hydrochloride as a model drug. The prepared formulations are biocompatible and give effective release of anasthetic agent. The result for this study suggests that mepivacaine hydrochloride thermoreversible gel may offer an alternative to injection anasthesia.
