Pyrazole belongs to the “diazole” class of heterocycles and is the most important moiety found in a large number of pharmaceutical agents. One of the earliest methods of pyrazole synthesis is refluxing the contents over hot water bath for few hours with constant stirring leading to the synthesis of a single compound in a particular yield. Overcoming the disadvantages of reflux method, newer technologies like one pot multicomponent synthesis, solution free synthesis, solid support synthesis, microwave and ultrasound synthetic technologies along with solution phase and solid phase combinatorial synthetic procedures are being adopted with the advantages of getting compounds in high yields in a lesser time duration. In the present review, an attempt has been made to describe the various development stages in the synthesis of pyrazole analogues.
