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The Subsistence of Tonic-clonic Threshold in F1 and F2 Generation: A Study in Bang Sensitive Mutant of Drosophila on Exposure to Carbamizapine | Abstract
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Abstract

The Subsistence of Tonic-clonic Threshold in F1 and F2 Generation: A Study in Bang Sensitive Mutant of Drosophila on Exposure to Carbamizapine

Author(s): Harini BP

The dose dependent action of carbamizapine an antiepileptic drug has played a pivotal role in diminishing the Seizure effect efficiently and the bangsensitive mutants provides an efficient system to study genetic, neurological, and behavioral mechanisms mediating these effects. Interestingly, the study has also revealed that carbamizapine do not have a prolonged threshold effect on the subsequent generation, the concentration of the dose is indirectly proportional to the tonic-clonic activity and has an important role in regulating behavior through metabolism; such studies should be useful for understanding the multiple effects on behavior and health. Despite the sources of complexity, the amount of research accomplished has pushed the fruit fly to the forefront of behavioral genetics research.