This study was done to determine the seroprevalence of HIV in High risk Groups in Kurnool Medical College, India. This study was conducted during April 2011 to March 2012 and included 1197 cases which included FSW (Female Sex Workers) and STD Clinic attendees , all of whom were screened for HIV, Among 888 FSW , 21 were found to be positive for HIV (2.30%). Among 309 STD clinic attendees, 25 were found to be positive for HIV(8.09%).