The present study is an attempt to determine the relationship between illness perception with depression and quality of life in patients with psoriasis. This is a correlational descriptive study. The population of this study included all patients with psoriasis who referred to Haj Daie dermatology clinic in Kermanshah in the fall of 2015. 80 patients were selected from this population through convenience sampling. The brief illness perception questionnaire (brief IPQ-R), Beck’s Depression questionnaire (BDI-II) and quality of life questionnaire (SF-36) were used to collect the data. Data were analyzed by mean, SD and Pearson correlation. The results showed that there is a significant positive relationship between illness perception, quality of life and its components. The results also showed that there is a statistically negative relationship between illness perception and depressive symptoms. According to the results the authors are recommend to provide an appropriate training and counseling programs patients with psoriasis to improve results of treatment , quality of life.