This study aimed to investigate the relationship between efficiency and effectiveness among administrative staff of Zahedan University of Medical Sciences. The population consisted of 360 people. Based on Morgan table, 185 people were randomly selected as the study’s samples. To collect data, two researcher-made questionnaires were used: the 23-item Efficacy Questionnaire and the 27-item Effectiveness Questionnaire. After reviewing the items, a group of professors and experts confirmed face validity and content validity of both questionnaires. To determine the reliability of the questionnaires, they were distributed among 30 people out of the whole samples and Cronbach’s alphas of 0.91 and 0.90 were determined using the SPSS software. To determine the relationship between efficiency and effectiveness of staff of Zahedan University of Medical Sciences, Pearson Correlation test was conducted and a significant relationship was found. There was also a significant relationship between efficiency and effectiveness in terms of education level; however, the results showed no significant relationship between the mentioned variables in terms of gender, marital status, age and years of service.