Today, skeletal and muscular disorders are different between jobs and populations. Among the different job groups, the practitioners of health department especially the practitioners who work in hospitals experience higher job stress, so the amount of the skeletal and muscular disorders are more widespread among them. Due to the previous matters and also the importance of the health of this job group in providing the patients' health services, it is necessary to investigate the amount of skeletal and muscular disorders among them. Therefore, this research is done with the goal of investigating the skeletal and muscular disorders among surgery room personnel in Zahedan medical and educational hospitals. This research is descriptive and analytical. It is done on 112 personnel who are selected by census. In order to collect information, a questionnaire was used that has 2 parts. The first part is related to demographic information and the second part is related to Nordic standard questionnaire. Finally, after collecting the questionnaires, the data were analyzed by SPSS 19 soft-ware, descriptive statistics, Pearson Correlation, Analysis of variance (Anova) and independent T-test. The results of this research show that the individuals' age average is 30.95 ± 7.76; 41 individuals were single and 88individuals were woman. During the last year, 59 individuals of surgery room personnel (48.7%) had wrist pain, 41 individuals (36.6%) had shoulder pain, 55 individuals (49.1%) had backache and 41 individuals (36.6) had neck pain at least once. The relationship between marital status, Sex, age, work experience and skeletal and muscular disorders was not meaningful (P>0.05). In overall, the research results show that the skeletal and muscular disorders are widespread among surgery room personnel. It is clear that the working pressure on the individuals' body can decrease the physical performance of nurses and also it can decrease providing services to the patients and cause financial, economical and physical losses.