Tithonia diversifolia have properties of insulin to lower blood glucose levels, such as phenolic compounds, terpenoids and flavonoids. This study aimed to anti-hyperglicemic activity of ethanol extracts and n-hexane fraction, acetate-etyl fraction, and the remaining fraction of leaves from Tithonia diversifolia on male white mice. This study use five treatment groups: control group is negative, extract, n-hexane fraction, acetate-etyl fraction and the remaining fraction. Each group is given treatment by name the group, except for the control group. The dose used for each group is the same, ie 10.78 mg / kg. Treatment was given for 21 days, followed by taking the measurements of blood glucose levels on days 0, 7th, 14tth and 21st. Calculation of blood glucose levels is done by cutting the tip of the mice’s tail to get the blood was measured using glucotest. The results showed all dose treatment were not significantly affect blood glucose levels of male white mice decreased (P> 0.05). The research showed that ethanol extract, hexane fraction, ethyl acetate fraction, the remaining fraction leaves of Tithonia diversifolia have no ability to lower blood glucose levels male white mice.
