The selected plant leaves, Talinum triangulare leaf extract (40 and 80 mg/kg bw) seems to be more efficient in the control of type II diabetes. Oral administration of aqueous extract of TT is able to control the diabetes induced alterations in enzymes related to carbohydrate metabolism. Both antioxidants like ascorbate, Vitamin C, Vitamin E and TTH and antioxidant defense enzymes like SOD, CAT and GPx levels also regulated by the supplementation of TT leaf extract to the rats during diabetes.