Increment of lipoprotein(a) [Lp (a)] and LDL_C and decrement of HDL_C concentrations, are CAD risk factors. Probably Lp(a) not been affected by training and it is resistant against exercise stimulation. The aim of this cross-sectional study was to determine and compare of Lp(a), LDL_C and HDL_C concentrations in selected groups. This analytical study was designed in four groups (N=4*13) of subjects (15-25 yrs) who were voluntarily participated and randomly selected from speed (age: 20.77 ± 3.14, BMI: 19.09 ± 0.97 kg/m²), semi-endurance (age: 19.70 ± 3.42, BMI: 20.25 ±1.74 kg/m²) , endurance (age: 22.61 ± 2.96, BMI: 19.98 ± 2.32 kg/m²) runner females and sedentary females (age: 20.92 ± 2.43, BMI: 23.70 ± 2.29 kg/m²). Fasting serum concentrations of Lp(a) (speed: 14.00 ± 9.55, semi-endurance:17.00 ± 10.93, endurance:15.30 ±14.58, control: 12.23 ± 10.93 mg/dl), LDL_C (speed: 82.53 ± 17.74, semi-endurance:77.76 ± 12.57, endurance:94.38 ± 26.00, control: 78.61 ± 15.95 mg/dl) and HDL_C (speed: 63.92 ± 13.91, semi-endurance: 60.00 ± 17.76, endurance: 63.92 ± 13.37, control: 60.70 ± 18.24 mg/dl) analysis with ELISA method. Data compared with kolmogorov-smirnov, Levine and ANOVA statistical tests (p ≤ 0.05). Results demonstrated that differences of Lp(a), LDL_C and HDL_C concentrations between groups were not significant. Comparison of serum concentrations of Lp(a), LDL_C and HDL_C in speed, semi-endurance and endurance with control groups to determine the training effects on these risk factors were not significant. It seems that the findings of previous and this study, Lp(a) not been affected by exercise and it is resistance against training stimulation. Therefore physical activity has not any desirable effect on Lp(a) concentration. So, to clarify the possible effect of exercise on Lp(a), more study must be designed and implemented.
