Red clover (Trifolum protense) is one of the wild pharmaceutical plants which can affect reproductive physiology because of its phytoestrogen properties. Sixty female mice from Balb/C race were divided randomly into four groups with 15 members in each group. Hydro alcoholic extract of red clover in 50, 100, and 200 mg/kg doses was given to mice in drinking water for 30 days. At the end of period, ovaries were separated and by using prepared slides, the numbers of corpus luteum and graph follicle were measured. In next stage, after mating the treatments, fertility was measured using the number of embryos in uterine branches. Results showed that the amount of follicle was reduced by increasing the dose of extract and also corpus luteum was decreased considerably in 100 mg/kg group (p<0.05). Fertility of all experimental groups was increased in proportion to control group. According to results, red clover’s extract can affect reproduction physiology dose dependently by decreasing corpus luteum and follicle graphs and increasing fertility.
