In order to investigation of safflower cultivars reaction to different fertilizer, an experimental was carried out in a split plot design based on RCBD with three replications for 2011-2012 year in research farm of Islamic Azad University of saveh, Iran. Treatments were included different fertilizer(bio and chemical fertilizer) in six levels as main plots and spring planting (25 March) and winter safflower varieties as sub plots in three levels (Varamin295, Zarghan279, Goldasht).The result showed that all treatment except than harvest index significant in main factor levels (fertilizers). High plant and seed yield was significant in sub-factor levels (varieties). The result of interaction effect showed that highest seed yield to obtain of Varamin295 variety (3512 kg.ha-1 in a5b3 treatment).
