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The effects of Anderoctonus Crassicauda scorpion venom in the treatment of Diabetes Mellitus type 1 in Animal models | Abstract
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Abstract

The effects of Anderoctonus Crassicauda scorpion venom in the treatment of Diabetes Mellitus type 1 in Animal models

Author(s): Leila Roudbari* and Sohrab Imani

Diabetes Mellitus is one of the most prevalent endocrine disorders in the world [4]. The symptoms include polydipsia and polyuria [11,14]. Scorpion venom contains various proteins including phospholipase A2, which has been extensively studied secondary to its presumptive medical effects [12]. In the following research, the effects of Anderoctonus Crassicauda scorpion venom in diabetic rats was studied. Diabetes was induced in rats by using alloxan monohydrate. In this study, Wistar rats with a mean body weight of 220 ± 30 gr were randomly selected. Twenty five rats were divided into five groups including the control(non diabetics) , Diabetic control, and three treatment groups and underwent observation for a period of 8 weeks. Blood samples were taken on schedule, and blood glucose level was measured using Glucometer. At the end of the 8-week period, significant difference was found between the treatment group receiving a higher dose of scorpion venom and Analysis of variance (ANOVA) was applied in our statistical data with a P value of <0.05 . Hence, it can be concluded that scorpion venom is effective in treating the pancreatic Beta cells.