One of the important functions of defense system is the production of immune components that protects body against many invasive agents. The purpose of the recent research was to investigate the effect of one over heavy exercise session is serum level of immunogbgins (IgG, IgA and IgM) in SepakTakraw athletes. 35 professional SepakTakraw athletes by average age 27±8 who have participated in best league of country and invited to cooperate purposefully, were selected. In this research 30 seconds wingate test was used to evaluate aerobic ability. Blood samples collected before, immediately after and 2 hours after exercise and immunoglobins measured by Neflormetric method. The results of this study indicated that, serum levels of IgA and IgM before, after and two hours after exercise did not meaningfully change whereas the amount of IgG during exercise changed significantly (p<0.05). The results showed that short time aerobic exercise has meaningful effect on serum IgG level of SepakTakraw athletes, but hasn’t meaningful effect on their serum levels of IgA and IgM
