Ficus glumosa belongs to the family moraceae and the genus ficus. This study was aimed at investigating the methanol extract of the stem back of Ficus glumosa for antidiarrhoeal activity using castor oil induced diarrhoea in mice. The effects of this extract on perfused isolated rabbit ileum were also evaluated. The methanol extract produced a dependent relaxation of the rabbit ileum. The extract protected the mice against diarrhea the dose of 20mg/kg bodyweight produced the highest protection (60%). Also as regards to the other two doses (40 and 80 mg/kg) produced 40 and 20 % protections respectively. The acute toxicity test revealed the median lethal dose (LD50) values for the extract is found to be 2.154 mg/kg bodyweight. These results obtained revealed that the methanol leaves extract possess pharmacological activity against diarrhoea and may possibly explain the use of the plant in traditional medicine.
