The goal of the present study was to determine effect of endurance training and to supplement aqueous extract of fenugreek seed on visfatin and vaspin levels in diabetic rats with streptozotocin. Material and Methods: Diabetes was induced by intraperitoneal injection of streptozotocin to 96 male Wistar rats (weight of 200-250 g and age of 12 weeks old). The rats were randomly divided into 8 groups: endurance training and fenugreek with dose of 1.74 g/kg, swimming endurance training, endurance training and fenugreek with dose of 0.87 g/kg, swimming endurance training and glibenclamide, diabetic control group, fenugreek group with dose of 0.87 g/kg, fenugreek group with dose of 1.74 g/kg and glibenclamide group. Swimming endurance training was performed for 6 weeks, 5 days a week and 1 h a day, in a water tank. In each dose of glibenclamide medicine, fenugreek extract and saline solution were orally fed to the subjects using gastric gavage. Results: The results showed that combination of endurance training and aqueous extract of fenugreek seed with dose of 1.74 g/kg significantly decreased plasma visfatin levels but combination of endurance training and aqueous extract of fenugreek with dose of 1.74 g/kg did not have any significant effect on Vaspin plasma levels. Conclusion: Considering the presented results in this research which showed that swimming endurance training and extract of fenugreek seed were effective on decrease of visfatin, it can be said that endurance training and fenugreek plant could be probably regarded a preventive or treatment method for diabetes.
