Background and Objective: Fitness experts reported a close relationship between exercise and immunity system. The main purpose of this study is to evaluate the effect of carbohydrate (CHO) supplementation during 60-minute running with 70 percent Vo2max on the serum IL-6. Methods: Nineteen students from University of Imam Hussein (AS) with of 24.89 ± 2.37 year of aged participated in this study and divided into experimental (CHO supplementation) and control (placebo supplementation) groups by randomly. All subjects completed an exercise test for 60 minutes running with 70% Vo2max on treadmill. Oral CHO or placebo supplementation ingested in 4 times: at first and in 15, 30 and 45 min of exercise test in experimental and control groups orderly. Blood sampling was performed before and immediately after each exercise test. Results: The findings show that serum IL-6 was increased after exercise test in two groups. But this increase was lower in experimental than control groups. Conclusion: CHO supplementation has an importance role in control IL-6 as inflammation cytokine during exercise
