Macroinvertebrates of the shores of the Great Kwa River were sampled monthly between August 2011 and January 2012 using the kick sampling technique and Van Veen Grab methods. The distribution of organic matter, substratum texture and current velocity were accounted for the variations of species composition, taxonomic richness and total abundance at the two stations. The most dominant taxonomic order was Decapoda represented mostly by Litopaenaeus vannamei (84.3%) followed by Johngarthia logostoma (4.45%) and Lymnaea species (4.85%) in Gastropoda. The abundance of Litopaenaeus vannamei is attributed to the fact that they are filter feeders that feed on the mud particles. High human activities around station two which released waste into the River accounted for the poor species richness.
