The prevalence of coronary artery disease (CAD), mortality and financial burden of those in Iran is increasing. Creating an active lifestyle with physical activity is the best prevention of CAD and its risk factors. The aim of this Cross-sectional study was compare of serum concentration of Fibrinogen, Homocysteine, Lipoprotein(a) and Glycosylated Hemoglobin in selected groups (Active, Sedentary, and CAD) of men (40-55 yrs); who were voluntarily participated, was based on NHIS and PA-R questionnaire (N=3*15). Fasting blood sample was taken for measuring serum concentration of fibrinogen [A: 287.86 ± 51.56, S: 299.80 ± 49.21 and CAD: 307.20 ± 63.80 mg/dl], Homocysteine [A: 11.73 ± 2.62, S: 12.40 ± 3.86 and CAD: 11.96 ± 5.11 μmol/L], Lipoprotein(a) [A: 18.06 ± 11.11, S: 22.06 ± 13.99 and CAD: 28.33 ± 7.20 mg/dl ] and Glycosylated Hemoglobin [A: 4.26 ± 0.36, S: 4.73 ± 13.37 and CAD: 5.25 ±1.32%]. Data analysis with ANOVA and Kruskal-Wallis tests (p ≤ 0.05). Mean differences of Homocysteine (p=0.898) and fibrinogen (p=0.630) between groups were not significant. Mean differences of Lipoprotein(a) between active and CAD group was significant (p=0.009). Mean differences of Glycosylated Hemoglobin between active and CAD (p=0.002) and between inactive and CAD (p=0.046) were significant. Therefore, physical activity has not any desirable effects on these risk factors in this study and more studies need to be done to clarify the optimum levels of intensity, duration and type of exercise for desirable change in these risk factors levels.
