Der Pharmacia Lettre
Abstract
Author(s): Lakshmi K.S, Vadivu R
The in vitro and in vivo anti-snake venom activities of various extracts of the leaves of
Symplocos cochinchinensis (Lour.) S.Moore ssp. laurina (Symplocaceae) were studied against
Russell�¢����s viper venom. The in vitro study was carried out by the inhibition of the in vitro Human
RBC lysis and the in vivo study was carried out by using Swiss albino mice in modifying the
lethal effect of the test dose of the Russell�¢����s viper venom. In in vivo model the effectiveness of the
extract was evaluated by oral administration of two different doses (200 and 400mg/kg) of the
methanolic extract of the leaves of Symplocos cochinchinensis 5 minutes prior to the injection of
the venom. The extract markedly decreased the percentage of mortality in venom induced toxicity
in mice at the dose of 400mg/kg b.w which indicates the significant anti-snake venom activity of
the plant there by justifying its use in the indigenous system of medicine.
