Forty African giant rats (AGRs), (Cricetomys gambianus) were used for the morphometric, morphologic, histologic and histochemical studies. The rats were sacrificed according to Adeyemo and Oke (1990) and the Mandibular Salivary glands were dissected out. The weight and length of the Mandibular Salivary gland were measured in grams and centimeter, respectively. Transverse sections of the mandibular salivary glands were stained with Haematoxylin and Eosin for normal histological studies. For histochemical studies, transverse sections were stained with Alcian Blue (AB), Periodic Acid Schiff (PAS) and Alcian Blue-Periodic Acid Schiff (AB-PAS) to determine the nature of their secretions. Grossly, the mandibular salivary glands were observed to be lobulated, paired, roughly square shaped and were located ventral to the parotid salivary glands. The mean weight and length of the mandibular salivary glands were 0.78 ± 0.02 g, and1.68 ± 0.049 cm, respectively. The mandibular salivary glands were observed to have few serous acini with numerous mucous acini and were AB and PAS positive.
