In the current research work, a series of novel title compounds, N-(3-(4-chloro phenyl)-2,5-diphenyl- 3,3a-dihydro-2H-pyrazolo[3,4-d]thiazol-6(5H)-yl)-2-(6,7-dihydrothieno-[3,2-c]pyridine-5(4H)-yl) acetamide (7a-h) were synthesized by reaction of N-(5-(4-chlorobenzylidene)-4-oxo-2-phenylthiazolidin- 3-yl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetamide (6a-h) with phenyl hydrazine in presence of acetic acid. Their structures were characterized by elemental and spectral analysis. All the synthesized compounds were screened for their in-vitro antimicrobial activity, also MIC values of these compounds were determined. The investigation of antimicrobial screening data revealed that most of the compounds tested have demonstrated congruent activity. In summary, preliminary results indicate that, the compounds 6g, 6f ,7g and 7f found to possess better antibacterial activity than Tetracycline (Reference standard) in MIC(Minimum inhibitory concentration), also compounds 6f ,7f and 7h found to possess better antifungal activity against Trichphyton longifusus and Candida glabrata than Miconazole (Reference standard).
