Amlodipine is one of the calcium channel blockers havingdihydropyridine group, used as an antihypertensive drug.A series of novel ureaandthioureaderivativesofamlodipine(1) were prepared by reacting (1) with various substituted isocyanates/isothiocyanates in the presence of triethylamine in THF at 50 °C. Their structures were established by IR, 1H, 13CNMR, Mass spectral data and C, H, N elemental analysis. Their antimicrobial activity was evaluated and the title compounds exhibited moderate antimicrobial activity.
