A few mixed ligand transition metal carbodithioate complexes of the general formula formula [M(AADTC)x ] and [M(ATDTC)x ] M=Au,Ru A series of new bidentate ligands are dithiocarbamates of 4-Amino anti-pyrene and 2- aminothiozole (AADTC, ATDTC) were prepared by new synthetic methods, as the sodium salt. In the reaction of Chloroauric acid and Ruthenium Chloride with aadtc and atdtc the corresponding complexes were prepared. The complexes was characterized by Elemental Analysis, IR, ESR, H 1NMR and TGA-DTA and screened for their antimicrobial activity against four bacterias (Staphylococcus aureus, Bacillussubtilis, Escherichia coli, Pseudomonas aeruginosa,) and two fungis (Candida albicans and Candida tropicalis) by disk diffusion method. All the complexes exhibited prominent antimicrobial activity against tested pathogenic strains.