The one pot reaction of pyrazolone3with malononitrile , ethylacetoacetate in presence of aromatic aldehyde , ammonium acetate and/or piperidine gave compounds 4-6 .Reaction of compound 4 with ammonium thiocaynate , formamide / formic acid and acetic anhydride gave compounds 7-9. Reaction of compound 5 with acetic anhydride followed by hydrazine hydrate gave compounds 10 and 11 respectively . Reaction of pyrazolone 3 with glucose , phenyl isothiocaynate ,nitrous acid /aniline , aromatic aldehyde have also been taken onto consideration to give compounds 12,13,15 and the α ,β –unsaturated ketone 16 . Compound 16 was used as key intermediate for preparation of various heterocyclic compounds via its reaction with pyrazolone3 ,hydrazine hydrate , hydroxylamine hydrochloride , urea , thiourea , ethylcyanoacetate / sodium ethoxide , malononitrile / ammonium acetate or sodium ethoxide and also with ethyl acetoacetate / sodium ethoxide . The newly synthesized compounds were characterized by IR, 1HNMR ,mass spectral data. The antitumor and biological activity has also been taken in consideration.
