Synthesis of Schiff’s base 1-[(2, 4-difluorophenyl)-2-(1H-1, 2, 4-triazol-1-yl)] ethanone thiosemicarbazone (1A) prepared by condensation of 1-(2,4-difluorophenyl)-2-[1(H)-1,2,4-triazol-1-yl] ethanone with thiosemicarbazide, followed by cyclization to 2-(2,4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1-ylmethyl)]-3-acetyl-5-acetylaminothiadiazoline (2A) using acetic anhydride and finally hydrolysis of (2A) to form 2-(2,4-difluorophenyl)-2-[(1H)- 1,2,4-triazol-1-ylmethyl)]-3-acetyl-5-amino-thiadiazoline (3A) using hydrazine hydrate, all compounds having antifungal activities are reported.
