Some novel compounds are synthesized using the substitution of chlorine in 2,4,6-trichloro-striazine by some moieties having structural as well as biological importance and not which are anti infective agents. In this manner 19 novel compounds are prepared and they are subjected to antibacterial and antifungal screening. Prior to this the synthesized compounds are duly characterized by IR and 1H-NMR spectral analysis. These compounds reveal substantive antibacterial activities against some randomly chosen both gram +ve & gram-ve bacteria. The promising results are in support of the fact that the compounds are worth to be optimized for some novel drugs in future.