In the present study, two series of novel histone deacetylase [HDAC] inhibitors were designed, synthesized and their in vitro anticancer activity were evaluated. in the first series, we use the amino acids phenyl alanine, leucine and tyrosine as the surface recognition and capping groups, while in the second series, we use p- substituted a anilines as the surface recognition and capping groups, The structures and purity of the targeted compounds were confirmed by TLC, FTIR, H-NMR and mass spectroscopy and their anticancer activity were evaluated by using HeLa nuclear extract and normal embryonic fibroblasts cell lines. All the synthesized compounds show good anticancer activity, represented by their growth inhibition rate percent on Hela cell line and compound [IBD] show the best safety index[SI] that represented by its cytotoxic activity on cancer cell line while sparing the normal cell line.
