Der Pharmacia Lettre
Abstract
Author(s): Nagesh H. Aloorkar, Manish S. Bhatia
A novel polymer, hydroxypropyl methylcellulose (HPMC) chemically modified by reacting with
maleic anhydride was synthesized. FTIR and NMR spectroscopy, DSC analysis and
determination of physicochemical property like viscosity were used to confirm the formation of
novel polymer. Ibuprofen, paracetamol and diclofenac sodium matrix tablets were prepared
employing HPMC and novel modified HPMC to evaluate the effect of chemical modification on
drug release properties of HPMC. Drug release was found to be increased from modified HPMC
matrices and unlike HPMC, release mechanism was found to be due to polymer erosion. Thus, it
can be concluded that biocompatible chemical modifications of polymers could make better
options accessible for specific formulation objectives.
