The Zn (II) complex of Schiff base derived from salicyladehyde and acetazolamide have been synthesized keeping in view that some metal complexes are found to be more potent than their parent drugs. The synthesized complex is characterized on the basis of elemental analysis, conductivity, magnetic measurements, particle size analysis, IR and NMR spectral studies. Comparative antibacterial behavior of Schiff base with their complex has also been studied.