A novel series of the benzene-(1/, 4 /-di-imine)-4, 4-di-hydroxy-di-phenyl (2a-i) , benzene-(1/. 4/-di-imine)- substituted-4, 4- diphenylamine (3a-i) and benzene-(1/, 4/-di-imine)-substituted-10H-di- phenothiazine (4a-i) were prepared by the reaction of 1, 4-di-imine with different aromatic aldehydes in excellent yield. Elemental analysis, 1R, H1NMR, C13NMR and mass spectral data established identification of the compounds (4a-i) was evaluated for their antimicrobial & antifungal activity.