A new series of Schiff bases of 5-sulphamoyl isatin (V) were synthesized by reacting various substituted aromatic
aldehydes with 3-hydrazino-5-sulphamoylisatin (IV). The 3-hydrazino-5-sulphamoylisatin was synthesized by
reacting 5-sulphamoylisatin with hydrazine hydrate. All the synthesized compounds were characterized by means of
their IR, 1HNMR and Mass spectroscopic data. The designed compounds were screened for anticancer activity
against Ehrlich Ascites Carcinoma (EAC) in Swiss Albino mice. Antitumor effect was determined by evaluating
tumor volume, viable tumor cells count, non-viable tumor cells count and mean survival time. The standard
antitumor drug used was 5-Fluorouracil. The results suggest that the compounds Ve, Vf, Vi and Vj exhibited
significant antitumor activity.
