Carboxy Methyl Cellulose (CMC) is a compound made from durian seed, where durian seeds is converted into the powder by the method of addition of methanol, propanol and water. Three consecutive process involves are the process of alkalization, carboxymethylamine, neutralization in the process of synthesis CMC. The first process are made by reacting NaOH and ClCH2COONa with NaOH 22; 32.5 g and 20 ; 32 g ClCH2COONa respectively. Acetic acid is added is used in the neutralization process, during the heating process in the oven. The overall results for each degree of substitution; viscosity; pH; water content; NaCl concentration; purity and yield of 0.76 - 0.77; 6-8 cP; 8; 8.7 to 17.7 %; 2.06 to 2.24 ; 97.76 to 97.96 % ; and 93.5 to 97.5 % respectively. Based on the research results obtained, it can be concluded that the CMC is of good quality as a filler.