The purpose of present study was to synthesize psyllium-g-poly (N-vinyl-2-pyrollidone) using microwave assisted synthesis. Microwave assisted graft co-polymerisation of N-vinyl-2-pyrollidone on psyllium husk was optimised using two factor, three level central composite experimental design. The observation obtained from optimization study displayed that higher concentration of ammonium per sulphate and lower concentration of N-vinyl pyrollidone increases the grafting efficiency. The graft coplymerised psyllium gel was also evaluated for its mucoadhesive properties. Mucoadhesion was determined by using modified physical balance method and it is found that there is two fold increase in mucoadhesion in case of psyllium-g-poly(N-vinyl-2-pyrollidone) and in vitro release study showed the sustained release of drug metronidazole over a period of 20 hrs in case of psyllium-g-poly(N-vinyl-2- pyrollidone).
