A new series of 4-(3-(3-(4-substituted phenyl)-4, 5-dihydroisoxazol-5-yl)-1H-indol-2-yl) phenol (5a-5f) were synthesized for analgesic activity. Compounds 5b, 5c and 5d have significant analgesic activity of this series. All compounds were screened in vivo for their analgesic activity and acute toxicity studies. The structural assignment of these compounds has been made on the basis of elemental analysis, IR and 1H-NMR, LCMS data.
