Substituted Schiff’s bases (2a-m) have been prepared by the treatment of 2-chloro-6- methxoyquinoline-3-carbaldehyde (1) with different arylamines, which on reaction with NaBH4 furnish our target molecule (3a-m). The structures of the synthesised compounds have been assigned on the basis of elemental analyses, IR, NMR and mass spectral studies. The compounds were evaluated for antimicrobial screening against Gram positive & Gram negative bacteria and fungal strain such as Aspergillus niger. Most of the compounds showed significant activity against all the species of bacteria and fungi.
