A series of 3-arylidenechroman-4-one derivatives (1-16) have been synthesized in good yields from chroman-4-one and different substituted aldehydes by the Claisen-Schmidt condensation. All the synthesized compounds were characterized by using spectroscopic analyses including IR, 1H NMR, 13C NMR, EIMS and HREIMS. The synthesized compounds were screened for in vitro inhibitory effects on aggregation of washed rabbit platelets induced by adenosine diphosphate (20 μM) and collagen (10 μg/mL). Compounds 1 (81.3%), 11 (88.7%), and 13 (85.0 %) were showed potent inhibitory effects on ADP-induced aggregation activity, in which their structures possessed 2-thiophene, 3,5-dimethoxybenzene and 2,3-dimethoxybenzene moieties in the B-ring, respectively
